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NNC 26-9100

Names

[ CAS No. ]:
199522-35-5

[ Name ]:
NNC 26-9100

[Synonym ]:
Pam3CSK4 Biotin

Biological Activity

[Description]:

NNC 26-9100 is a selective somatostatin sst4 receptor full agonist (Ki: 6 nM, EC50: 2 nM). NNC 26-9100 decreases total soluble Aβ42, increases brain neprilysin activity and improves learning[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Somatostatin Receptor
Research Areas >> Neurological Disease

[References]

[1]. Michael Ankersen, et al. Discovery of a Novel Non-Peptide Somatostatin Agonist with SST4 Selectivity. J. Am. Chem. Soc. 1998, 120, 7, 1368-1373.

[2]. Sandoval KE, et al. Somatostatin receptor subtype-4 agonist NNC 26-9100 mitigates the effect of soluble Aβ(42) oligomers via a metalloproteinase-dependent mechanism. Brain Res. 2013 Jul 3;1520:145-56.  

Chemical & Physical Properties

[ Density]:
1.482g/cm3

[ Boiling Point ]:
731.167ºC at 760 mmHg

[ Molecular Formula ]:
C22H25BrCl2N6S

[ Molecular Weight ]:
556.35

[ Flash Point ]:
395.996ºC

[ Exact Mass ]:
554.04200

[ PSA ]:
100.96000

[ LogP ]:
6.14940

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.668

Related Compounds