Solidagonic acid

Names

[ CAS No. ]:
19941-91-4

[ Name ]:
Solidagonic acid

[Synonym ]:
2-Pentenoic acid, 5-[(1R,2S,3R,4aR,8aR)-3-(acetyloxy)-1,2,3,4,4a,7,8,8a-octahydro-1,2,4a,5-tetramethyl-1-naphthalenyl]-3-methyl-, (2E)-
(2E)-5-[(1R,2S,3R,4aR,8aR)-3-Acetoxy-1,2,4a,5-tetramethyl-1,2,3,4,4a,7,8,8a-octahydro-1-naphthalenyl]-3-methyl-2-pentenoic acid

Biological Activity

[Description]:

Solidagonic acid inhibits HSET motor activity by promoting the conversion from abnormal monopolar to bipolar spindles. Solidagonic acid suppresses fission yeast cell death and enables reversion of the mitotic spindles from a monopolar to bipolar morphology. Solidagonic acid showed the growth inhibitory activity on the seedlings of Lactuca sativa L. and Lolium multiflorum Lam[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Kinesin

Signaling Pathways >> Cytoskeleton >> Kinesin

[References]

[1]. Naoaki Kurisawa, et al. Kolavenic acid analog restores growth in HSET-overproducing fission yeast cells and multipolar mitosis in MDA-MB-231 human cells. Bioorg Med Chem. 2020 Jan 1;28(1):115154.

[2]. Hisashi Kato-Noguchi, et al. Allelopathy and Allelochemicals of Solidago canadensis L. and S. altissima L. for Their Naturalization. Plants (Basel). 2022 Nov 25;11(23):3235.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
464.9±28.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₃₄O₄

[ Molecular Weight ]:
362.503

[ Flash Point ]:
150.9±17.5 °C

[ Exact Mass ]:
362.245697

[ LogP ]:
6.49

[ Vapour Pressure ]:
0.0±2.5 mmHg at 25°C

[ Index of Refraction ]:
1.518

Related Compounds

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