Medronic Acid

Names

[ CAS No. ]:
1984-15-2

[ Name ]:
Medronic Acid

[Synonym ]:
MDP,Medronic acid
phosphonomethylphosphonic acid
MDP,Medronic acid,Methylenediphosphonic acid
methanediylbis(phosphonic acid)
MDP~Medronicacid
Medronic Acid
Methylenediphosphonic acid
Methylenebiphosphonic Acid
methylene biphosphonate
acide méthanediylbis(phosphonique)
Methanebisphosphonic Acid
Methanediphosphonic Acid
Medronic acid [USAN:BAN:INN]
METHYLENEBISPHOSPHONIC ACID
Medronic
methylenediphosphonate
Phosphonic acid, methylenebis-
EINECS 217-851-0
MDP
Methylenebis(phosphonic acid)
MFCD00002139
Methandiylbis(phosphonsäure)

Biological Activity

[Description]:

Medronic Acid (Methylenediphosphonic acid) is a methylene-substituted bisphosphonate. Medronic acid has affinity for and adheres to the surface of hydroxyapatite crystals in the bone matrix. This agent accumulates at sites of osteoid mineralization and can be used, complexed with radioisotopes in bone imaging.

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Ohta Y, et al. Salt Tolerance Enhancement of Liquid Chromatography-Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry Using Matrix Additive MethylenediphosphonicAcid. Mass Spectrom (Tokyo). 2014;3(1):A0031.

Chemical & Physical Properties

[ Density]:
2.1±0.1 g/cm3

[ Boiling Point ]:
583.2±60.0 °C at 760 mmHg

[ Melting Point ]:
197-199 °C(lit.)

[ Molecular Formula ]:
CH₆O₆P₂

[ Molecular Weight ]:
176.002

[ Flash Point ]:
306.5±32.9 °C

[ Exact Mass ]:
175.963959

[ PSA ]:
134.68000

[ LogP ]:
-4.11

[ Vapour Pressure ]:
0.0±3.5 mmHg at 25°C

[ Index of Refraction ]:
1.550

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
C: Corrosive;

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
S26-S36/37/39-S45

[ RIDADR ]:
UN 3261 8/PG 3

[ WGK Germany ]:
-

[ RTECS ]:
SZ9138000

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2931900090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2931900090

[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

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Related Compounds

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