Cyclopentanecarboxylic acid, 2-amino-4-methylene-, (1R,2S)- (9CI)

Names

[ CAS No. ]:
198022-65-0

[ Name ]:
Cyclopentanecarboxylic acid, 2-amino-4-methylene-, (1R,2S)- (9CI)

[Synonym ]:
Cyclopentane carboxylicacid,2-amino-4-methylene-,(1R,2S)-(9CI)

Biological Activity

[Description]:

Icofungipen is an orally active antifungal agent. Icofungipen is the representative of beta amino acids, is toxic against Candida species. Icofungipen protects infected mice survival from C. albicans infection[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

[In Vitro]

Icofungipen 对念珠菌有抑制作用，MIC 值为 16-64 μg/mL（24-48 h 处理时间）[1]。 Icofungipen 对 90% 的念珠菌的 MIC90 值为 8-32 μg/mL[1]。

[In Vivo]

Icofungipen（5-25 mg/kg；口服；每天两次，持续 7 天）在小鼠感染的致死模型中，剂量依赖性保护小鼠抵御白色念珠菌临床分离株的感染[1]。

[References]

[1]. Hasenoehrl A, et al. In vitro activity and in vivo efficacy of icofungipen (PLD-118), a novel oral antifungal agent, against the pathogenic yeast Candida albicans. Antimicrob Agents Chemother. 2006 Sep;50(9):3011-8.

Chemical & Physical Properties

[ Density]:
1.16g/cm3

[ Boiling Point ]:
277.4ºC at 760 mmHg

[ Molecular Formula ]:
C₇H₁₁NO₂

[ Molecular Weight ]:
141.17

[ Flash Point ]:
121.6ºC

[ Exact Mass ]:
141.07900

[ PSA ]:
63.32000

[ LogP ]:
1.06480

[ Vapour Pressure ]:
0.00123mmHg at 25°C

[ Index of Refraction ]:
1.528

Cyclopentanecarboxylic acid, 2-amino-4-methylene-, (1R,2S)- (9CI)

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

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