198022-65-0

198022-65-0 structure

Name: Cyclopentanecarboxylic acid, 2-amino-4-methylene-, (1R,2S)- (9CI)
Chemical Name: icofungipen
CAS Number: 198022-65-0
Molecular Formula: C₇H₁₁NO₂
Molecular Weight: 141.17
Catalog: Signaling Pathways Anti-infection Fungal
Create Date: 2016-01-16 03:08:36
Modify Date: 2024-01-03 12:16:20
Icofungipen is an orally active antifungal agent. Icofungipen is the representative of beta amino acids, is toxic against Candida species. Icofungipen protects infected mice survival from C. albicans infection[1].

Name	icofungipen
Synonyms	Cyclopentane carboxylicacid,2-amino-4-methylene-,(1R,2S)-(9CI)

Description	Icofungipen is an orally active antifungal agent. Icofungipen is the representative of beta amino acids, is toxic against Candida species. Icofungipen protects infected mice survival from C. albicans infection[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal
In Vitro	Icofungipen 对念珠菌有抑制作用，MIC 值为 16-64 μg/mL（24-48 h 处理时间）[1]。 Icofungipen 对 90% 的念珠菌的 MIC90 值为 8-32 μg/mL[1]。
In Vivo	Icofungipen（5-25 mg/kg；口服；每天两次，持续 7 天）在小鼠感染的致死模型中，剂量依赖性保护小鼠抵御白色念珠菌临床分离株的感染[1]。
References	[1]. Hasenoehrl A, et al. In vitro activity and in vivo efficacy of icofungipen (PLD-118), a novel oral antifungal agent, against the pathogenic yeast Candida albicans. Antimicrob Agents Chemother. 2006 Sep;50(9):3011-8.