Isoquinoline,1,2,3,4-tetrahydro-1-(phenylmethyl)-

Names

[ CAS No. ]:
19716-56-4

[ Name ]:
Isoquinoline,1,2,3,4-tetrahydro-1-(phenylmethyl)-

[Synonym ]:
(-+)-1-Benzyl-1,2,3,4-tetrahydro-isochinolin
1-phenylmethyl-1,2,3,4-tetrahydroisoquinoline
1,2,3,4-Tetrahydro-1-(phenylmethyl)isoquinoline
1-benzyl-1,2,3,4-tetrahydro-isoquinoline
1-benzyl-1,2,3,4-tetrahydroisoquinoline
Isoquinoline,1-benzyl-1,2,3,4-tetrahydro
(R,S)-Tetrahydrobenzylisoquinoline
1BnTIQ

Biological Activity

[Description]:

1-Benzyl-1,2,3,4-tetrahydro-isoquinoline is an endogenous metabolite present in Cerebrospinal_Fluid that can be used for the research of Parkinson's Disease[1][2].

[Related Catalog]:

Research Areas >> Neurological Disease

[In Vitro]

Endogenous metabolites is defined as those that are annotated by Kyoto Encyclopedia of Genes and Genomes as substrates or products of the ~1900 metabolic enzymes encoded in our genome. It is clear in the body of literature that there are documented toxic properties for many of these metabolites[1].

[References]

[1]. Lee N, et al. Endogenous toxic metabolites and implications in cancer therapy. Oncogene. 2020 Aug;39(35):5709-5720.

[2]. Kotake Y, et al. 1-Benzyl-1,2,3,4-tetrahydroisoquinoline as a parkinsonism-inducing agent: a novel endogenous amine in mouse brain and parkinsonian CSF. J Neurochem. 1995 Dec;65(6):2633-8.

Chemical & Physical Properties

[ Density]:
1.06g/cm3

[ Boiling Point ]:
358.7ºC at 760mmHg

[ Molecular Formula ]:
C₁₆H₁₇N

[ Molecular Weight ]:
223.31300

[ Flash Point ]:
180.1ºC

[ Exact Mass ]:
223.13600

[ PSA ]:
12.03000

[ LogP ]:
3.44490

[ Vapour Pressure ]:
2.5E-05mmHg at 25°C

[ Index of Refraction ]:
1.588

Safety Information

[ HS Code ]:
2933499090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%