VU6001376

Names

[ CAS No. ]:
1968546-34-0

[ Name ]:
VU6001376

Biological Activity

[Description]:

VU6001376 is a potent and selective positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu4 PAM) with an EC50 of 50.1 nM[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR

Research Areas >> Neurological Disease

[Target]

mGlu4:50.1 nM (EC50)

[References]

[1]. Bollinger SR, et al. Discovery, Structure-Activity Relationship, and Biological Characterization of a Novel Series of 6-((1 H-Pyrazolo[4,3- b]pyridin-3-yl)amino)-benzo[ d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGlu4). J Med Chem. 2019 Jan 10;62(1):342-358.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₄F₂N₆OS

[ Molecular Weight ]:
400.41

Related Compounds

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