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ODN 20844

Names

[ CAS No. ]:
1964506-29-3

[ Name ]:
ODN 20844

Biological Activity

[Description]:

ODN 20844, a guanine-modified inhibitory oligonucleotide (INH-ODN), is a TLR7 and TLR9 (Toll-like receptor) inhibitor, and its parent is INH-ODN 2088. ODN 20844 disrupts TLR7- and TLR9-mediated immune cell immune responses. ODN 20844 sequence: 5'-TCCTGGCGc7GGGAAGT-3'[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR)
Research Areas >> Infection
Research Areas >> Inflammation/Immunology

[Target]

TLR7

TLR9


[In Vitro]

ODN 20844 (0.01-10 μM, 24 h) can effectively block TLR9-mediated IFN-α release and inhibit IL-6 secretion in human peripheral blood mononuclear cells[1]. ODN 20844 (0.01-10 μM, 24 h) has better inhibitory effect on imiquimod-induced IL-6 secretion in human B cells than INH-ODN 2088[1].

[References]

[1]. Franziska Römmler, et al. Guanine-modified inhibitory oligonucleotides efficiently impair TLR7- and TLR9-mediated immune responses of human immune cells. PLoS One. 2015 Feb 19;10(2):e0116703.

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds