Megazol

Names

[ CAS No. ]:
19622-55-0

[ Name ]:
Megazol

[Synonym ]:
megazol
Nitroimidazole thiadiazole

Biological Activity

[Description]:

Megazol is an orally active antibacterial agent. Megazol has effective inhibitory against T. b. brueei with an EC50 of 0.01 μg/mL. Megazol can be used for the research of protozoan infections[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

EC50: 0.01 μg/mL (T. b. brueei)[1]

[In Vitro]

Megazol has effective inhibitory against T. b. brueei AnTat 1-9 with an EC50 of 0.01 μg/mL[1].

[In Vivo]

Megazol (i.p. or p.o.; 20, 80 mg/kg) shows cure the acute disease in T. b. brueei infected Swiss mice[1]. Megazol alone not causes cure of mice carrying a subacute infection with involvement of the central nervous system (CNS) [1]. Megazol have remission effect combined suramin, without further relapse from the CNS[1]. Animal Model: Swiss mice[1] Dosage: 20, 80 mg/kg Administration: i.p., p.o. Result: Cured infection at 20 mg/kg (i.p) and at 80 mg/kg (p.o).

Chemical & Physical Properties

[ Density]:
2g/cm3

[ Boiling Point ]:
532.6ºC at 760 mmHg

[ Molecular Formula ]:
C₆H₆N₆O₂S

[ Molecular Weight ]:
226.21600

[ Flash Point ]:
275.9ºC

[ Exact Mass ]:
226.02700

[ PSA ]:
143.68000

[ LogP ]:
1.53340

[ Vapour Pressure ]:
2.01E-11mmHg at 25°C

[ Index of Refraction ]:
1.921

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XI3525000

CHEMICAL NAME :: 1,3,4-Thiadiazole, 2-amino-5-(1-methyl-5-nitroimidazol-2-yl)-

CAS REGISTRY NUMBER :: 19622-55-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C6-H6-N6-O2-S

MOLECULAR WEIGHT :: 226.24

WISWESSER LINE NOTATION :: T5NN DSJ CZ E- BT5N CNJ A1 ENW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Klebsiella pneumoniae

DOSE/DURATION :: 100 nmol/L/20H

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 66,207,1979

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.