GW7604

GW7604 is an antiestrogen. GW7604 is the metabolite of GW5638, which is a high affinity estrogen receptor (ER) antagonist[1].

Signaling Pathways >> Others >> Estrogen Receptor/ERR

Research Areas >> Cancer

GW7604 is the presumed metabolite of GW5638 in breast (MCF-7) and endometrial (ECC-1) cell lines. GW7604 (0.1 nM-1 μM; 24 hours) inhibits both Estradiol (1 nM) and 4-hydroxytamoxifen (4-OHT; 10 and 100 nM) induction of TGF-alpha in a concentration related manner (1-1000 nM) in MDA-MB-231 cells[1]. Western Blot Analysis[1] Cell Line: MDA-MB-231 cells Concentration: 0.1 nM, 1 nM, 10 nM, 100 nM, 1 μM Incubation Time: 24 hours Result: Blocked the effect of estradiol (E2; 1 n M) in a concentration-related manner.

[1]. Bentrem D, et al. Molecular mechanism of action at estrogen receptor alpha of a new clinically relevant antiestrogen (GW7604) related to tamoxifen. Endocrinology. 2001 Feb;142(2):838-46.