195611-82-6

195611-82-6 structure

Name: GW7604
Chemical Name: gw7604
CAS Number: 195611-82-6
Molecular Formula: C₂₅H₂₂O₃
Molecular Weight: 370.44
Catalog: Research Areas Cancer
Create Date: 2018-04-30 06:19:38
Modify Date: 2024-01-09 16:00:48
GW7604 is an antiestrogen. GW7604 is the metabolite of GW5638, which is a high affinity estrogen receptor (ER) antagonist[1].

Name	gw7604
Synonyms	gw 7604

Description	GW7604 is an antiestrogen. GW7604 is the metabolite of GW5638, which is a high affinity estrogen receptor (ER) antagonist[1].
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Cancer
In Vitro	GW7604 is the presumed metabolite of GW5638 in breast (MCF-7) and endometrial (ECC-1) cell lines. GW7604 (0.1 nM-1 μM; 24 hours) inhibits both Estradiol (1 nM) and 4-hydroxytamoxifen (4-OHT; 10 and 100 nM) induction of TGF-alpha in a concentration related manner (1-1000 nM) in MDA-MB-231 cells[1]. Western Blot Analysis[1] Cell Line: MDA-MB-231 cells Concentration: 0.1 nM, 1 nM, 10 nM, 100 nM, 1 μM Incubation Time: 24 hours Result: Blocked the effect of estradiol (E2; 1 n M) in a concentration-related manner.
References	[1]. Bentrem D, et al. Molecular mechanism of action at estrogen receptor alpha of a new clinically relevant antiestrogen (GW7604) related to tamoxifen. Endocrinology. 2001 Feb;142(2):838-46.