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Corixetan

Names

[ CAS No. ]:
1952359-26-0

[ Name ]:
Corixetan

[Synonym ]:
Butanoic acid, 4-[[4-[3-[bis[2-[[(1,2-dihydro-3-hydroxy-1-methyl-2-oxo-4-pyridinyl)carbonyl]amino]ethyl]amino]-2-[[bis[2-[[(1,2-dihydro-3-hydroxy-1-methyl-2-oxo-4-pyridinyl)carbonyl]amino]ethyl]amino]methyl]propyl]phenyl]amino]-4-oxo-
4-{[4-(3-[Bis(2-{[(3-hydroxy-1-methyl-2-oxo-1,2-dihydro-4-pyridinyl)carbonyl]amino}ethyl)amino]-2-{[bis(2-{[(3-hydroxy-1-methyl-2-oxo-1,2-dihydro-4-pyridinyl)carbonyl]amino}ethyl)amino]methyl}propyl)phenyl]amino}-4-oxobutanoic acid

Biological Activity

[Description]:

Corixetan is a highly efficient thorium chelator. Corixetan can efficiently complex Th-227 with sufficient in vivo stability[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin

[Target]

Traditional Cytotoxic Agents


[References]

[1]. Ramdahl T, et al. An efficient chelator for complexation of thorium-227. Bioorg Med Chem Lett. 2016 Sep 1;26(17):4318-21.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
1320.8±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C50H61N11O15

[ Molecular Weight ]:
1056.08

[ Flash Point ]:
752.6±34.3 °C

[ Exact Mass ]:
1055.434814

[ LogP ]:
-3.84

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.671

Related Compounds