LXRβ agonist-2

Names

[ CAS No. ]:
1949801-52-8

[ Name ]:
LXRβ agonist-2

Biological Activity

[Description]:

LXRβ agonist-2 is a highly potent and β-selective liver X receptor (LXRβ) agonist with EC50 of 7 nM, displays 28.5-fold selectivity over LXRα (EC50=200 nM) and used in the treatment of atherosclerosis[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> LXR

[Target]

EC50: 7 nM (LXRβ), 200 nM (LXRα)[1]

[References]

[1]. Koura M,et al. Discovery of a 2-hydroxyacetophenone derivative as an outstanding linker to enhance potency and β-selectivity of liver X receptor agonist. Bioorg Med Chem. 2016 Aug 15;24(16):3436-46.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₂H₃₁F₆N₃O₇

[ Molecular Weight ]:
683.59

Related Compounds

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