Benzenemethanaminium,N-dodecyl-N,N-bis(2-hydroxyethyl)-, chloride (1:1)

Names

[ CAS No. ]:
19379-90-9

[ Name ]:
Benzenemethanaminium,N-dodecyl-N,N-bis(2-hydroxyethyl)-, chloride (1:1)

[Synonym ]:
Bialcol
Benzoxonium chloride
Cohortan
Bradophen
Absonal V
Lomades
Bactofen
Absonal
Orofar
Beloran

Biological Activity

[Description]:

Benzoxonium chloride is an anti-leishmanial agent. Benzoxonium chloride inhibits bacteria, certain protozoa, yeasts and non-spore forming organisms[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Parizi MH, et al. Antileishmanial Activity of Niosomal Combination Forms of Tioxolone along with Benzoxonium Chloride against Leishmania tropica. Korean J Parasitol. 2019 Aug;57(4):359-368.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₄₂ClNO₂

[ Molecular Weight ]:
400.03800

[ Exact Mass ]:
399.29000

[ PSA ]:
40.46000

[ LogP ]:
1.91290

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BO6475300

CHEMICAL NAME :: Ammonium, benzylbis(2-hydroxyethyl)dodecyl-, chloride

CAS REGISTRY NUMBER :: 19379-90-9

LAST UPDATED :: 199803

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C23-H42-N-O2.Cl

MOLECULAR WEIGHT :: 400.11

WISWESSER LINE NOTATION :: Q2K12&2Q1R &G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EGESAQ Egeszsegtudomany. (Kultura, POB 149, H-1389 Budapest, Hungary) V.1- 1957- Volume(issue)/page/year: 32,395,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1584 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory obstruction Skin and Appendages - primary irritation (after topical exposure)

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 10,55,1976