C.I. Direct Black 38

Names

[ CAS No. ]:
1937-37-7

[ Name ]:
C.I. Direct Black 38

[Synonym ]:
AZO BLACK
Chlorazol Black E
MFCD00066363
Chlorazol Black E,certified
2,7-Naphthalenedisulfonic acid, 4-amino-3-[(E)-2-[4'-[(E)-2-(2,4-diaminophenyl)diazenyl][1,1'-biphenyl]-4-yl]diazenyl]-5-hydroxy-6-[(E)-2-phenyldiazenyl]-, sodium salt (1:2)
C.I. Direct Black 38
Chlorazol Black
metablack
erieblackb
ERIE BLACK
2,7-naphthalenedisulfonic acid, 4-amino-3-[(E)-[4'-[(E)-(2,4-diaminophenyl)azo][1,1'-biphenyl]-4-yl]azo]-5-hydroxy-6-[(E)-phenylazo]-, disodium salt
black2embl
EINECS 217-710-3
Disodium 4-amino-3-[(E)-{4'-[(E)-(2,4-diaminophenyl)diazenyl]-4-biphenylyl}diazenyl]-5-hydroxy-6-[(E)-phenyldiazenyl]-2,7-naphthalenedisulfonate
black4embl

Biological Activity

[Description]:

Direct Black 38 is an azo dye. Direct Black 38 induces unscheduled DNA synthesis in liver and micronucleus in bone marrow of rats in vivo[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Beije B. Induction of unscheduled DNA synthesis in liver and micronucleus in bone marrow of rats exposed in vivo to the benzidine-derived azo dye, Direct Black 38. Mutat Res. 1987 Apr;187(4):227-34.

Chemical & Physical Properties

[ Density]:
1.61g/cm3

[ Melting Point ]:
109-110°C

[ Molecular Formula ]:
C₃₄H₂₅N₉Na₂O₇S₂

[ Molecular Weight ]:
781.728

[ Exact Mass ]:
781.111389

[ PSA ]:
303.61000

[ LogP ]:
11.91860

[ Index of Refraction ]:
1.768

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QJ6160000

CHEMICAL NAME :: 2,7-Naphthalenedisulfonic acid, 4-amino-3-((4'-((2,4-diaminophenyl)azo)(1,1'-biphenyl )-4-yl) azo)-5-hydroxy-6-(phenylazo)-, disodium salt

CAS REGISTRY NUMBER :: 1937-37-7

LAST UPDATED :: 199801

DATA ITEMS CITED :: 32

MOLECULAR FORMULA :: C34-H25-N9-O7-S2.2Na

MOLECULAR WEIGHT :: 781.78

WISWESSER LINE NOTATION :: L66J BZ CNUNR DR DNUNR DR DNUNR BZ DZ&&& DSWO HSWO INUNR JQ &-NA- 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7600 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 180 gm/m3/1H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1262 mg/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes in urine composition Kidney, Ureter, Bladder - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6825 mg/kg/13W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 34 mg/kg/60W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 13286 mg/kg/13W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 5 gm/kg

SEX/DURATION :: female 8-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - other postnatal measures or effects

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Unscheduled DNA synthesis

MUTATION DATA

TYPE OF TEST :: Body fluid assay

TEST SYSTEM :: Rodent - rat Bacteria - Salmonella typhimurium

DOSE/DURATION :: 300 mg/kg

REFERENCE :: IAEHDW International Archives of Occupational and Environmental Health. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.35- 1975- Volume(issue)/page/year: 49,177,1981 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 29,295,1982 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 29,295,1982 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-FINLAND;Carcinogen JAN 1993 OEL-FRANCE;Carcinogen JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1410 No. of Facilities: 704 (estimated) No. of Industries: 10 No. of Occupations: 27 No. of Employees: 16432 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1410 No. of Facilities: 298 (estimated) No. of Industries: 7 No. of Occupations: 12 No. of Employees: 11374 (estimated) No. of Female Employees: 5821 (estimated)

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H319-H350-H361d

[ Precautionary Statements ]:
P201-P280-P305 + P351 + P338-P308 + P313

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T:Toxic;

[ Risk Phrases ]:
R45;R63

[ Safety Phrases ]:
S53-S45

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
QJ6160000

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