Methyl (2Z)-3-(4-hydroxyphenyl)acrylate

Names

[ CAS No. ]:
19367-38-5

[ Name ]:
Methyl (2Z)-3-(4-hydroxyphenyl)acrylate

[Synonym ]:
4-Hydroxy MethylesterCinnaMatc
METHYL 4-COUMARATE
4-hydroxycinnamic acid methyl ester
Methyl trans-p-Coumarate
METHYL P-HYDROXYCINNAMATE
Methyl (2Z)-3-(4-hydroxyphenyl)acrylate
Methyl trans-4-Hydroxycinnamate
Methyl 4-hydroxyphenylacrylate
METHYL COUMARATE
METHYL 3-HYDROXYCINNAMATE
trans-4-Hydroxycinnamic Acid Methyl Ester
(E)-Methyl 3-(4-hydroxyphenyl)acrylate
4-hydroxyphenyl-acrylic acid methyl ester
2-Propenoic acid, 3-(4-hydroxyphenyl)-, methyl ester, (2Z)-
Methyl trans-p-hydroxycinnaMate
MFCD00157167
trans-p-Coumaric Acid Methyl Ester

Biological Activity

[Description]:

(E)-Methyl 4-coumarate (Methyl 4-hydroxycinnamate), found in several plants, such as green onion (Allium cepa) or noni (Morinda citrifolia L.) leaves. (E)-Methyl 4-coumarate cooperates with Carnosic Acid in inducing apoptosis and killing acute myeloid leukemia cells, but not normal peripheral blood mononuclear cells. Antioxidant and antimicrobial activity.

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Trachtenberg A, et al. Synergistic Cytotoxicity of Methyl 4-Hydroxycinnamate and Carnosic Acid to Acute Myeloid Leukemia Cells via Calcium-Dependent Apoptosis Induction. Front Pharmacol. 2019 May 9;10:507.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
306.6±17.0 °C at 760 mmHg

[ Melting Point ]:
138-140ºC

[ Molecular Formula ]:
C₁₀H₁₀O₃

[ Molecular Weight ]:
178.185

[ Flash Point ]:
132.8±13.7 °C

[ Exact Mass ]:
178.062988

[ PSA ]:
46.53000

[ LogP ]:
1.64

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.593

[ Storage condition ]:
Refrigerator

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36/37/39