Monomethyl auristatin E intermediate-14

Names

[ CAS No. ]:
1932791-56-4

[ Name ]:
Monomethyl auristatin E intermediate-14

Biological Activity

[Description]:

Monomethyl auristatin E intermediate-14 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₁₉NO₂

[ Molecular Weight ]:
221.30

Related Compounds

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