TAK-041

Names

[ CAS No. ]:
1929519-13-0

[ Name ]:
TAK-041

Biological Activity

[Description]:

TAK-041 is a potent and selective GPR139 agonist with an EC50 of 22 nM. TAK-041 has the potential for the research of negative symptoms associated with schizophrenia[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> GPR139

Research Areas >> Neurological Disease

[In Vivo]

TAK-041 (0.03-3 mg/kg; P.o.) improves social behavior in BALB/c mice[1]. Animal Model: BALB/c mice[1] Dosage: 0.03, 0.3, and 3 mg/kg Administration: P.o. Result: Dose-dependently improved the social behavior of BALB/c mice.

[References]

[1]. Reichard HA, et al. Discovery of TAK-041: a Potent and Selective GPR139 Agonist Explored for the Treatment of Negative Symptoms Associated with Schizophrenia [published online ahead of print, 2021 Jul 14]. J Med Chem. 2021;10.1021/acs.jmedchem.1c00820.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₅F₃N₄O₃

[ Molecular Weight ]:
392.33

TAK-041

Names

Biological Activity

Chemical & Physical Properties

Related Compounds