4H-1-Benzopyran-4-one,2-(4-chlorophenyl)-3-hydroxy-

Names

[ CAS No. ]:
19275-70-8

[ Name ]:
4H-1-Benzopyran-4-one,2-(4-chlorophenyl)-3-hydroxy-

[Synonym ]:
4'-chloro-3-hydroxyflavone
3-hydroxy-2-(4-chlorophenyl)-chromen-4(1H)-one
4'-Chloroflavonol
3-hydroxy-2-(4-chlorophenyl)-4H-chromen-4(1H)-one
3-Hydroxy-4'-chloroflavone
2-(4-chlorophenyl)-3-hydroxy-4H-chromen-4-one
4'-chloro-3-flavonol

Biological Activity

[Description]:

Tyrosinase-IN-4 (compound 34) is a potent inhibitor of tyrosinase. Tyrosinase is a copper-containing metalloenzyme that is responsible for the rate-limiting catalytic step in the melanin biosynthesis and enzymatic browning. Tyrosinase-IN-4 has the potential for the research of skin whitening agents and food preservatives[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Li J, et al. Recent advances in the design and discovery of synthetic tyrosinase inhibitors. Eur J Med Chem. 2021;224:113744.

Chemical & Physical Properties

[ Density]:
1.464g/cm3

[ Boiling Point ]:
416.8ºC at 760 mmHg

[ Molecular Formula ]:
C₁₅H₉ClO₃

[ Molecular Weight ]:
272.68

[ Flash Point ]:
205.9ºC

[ Exact Mass ]:
272.02400

[ PSA ]:
50.44000

[ LogP ]:
3.81900

[ Vapour Pressure ]:
1.08E-07mmHg at 25°C

[ Index of Refraction ]:
1.683

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.