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5,9-Dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methyl-2-buten-1-yl)-3,4-dihydro-2H,6H-pyrano[3,2-b]xanthen-6-one

Names

[ CAS No. ]:
19275-46-8

[ Name ]:
5,9-Dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methyl-2-buten-1-yl)-3,4-dihydro-2H,6H-pyrano[3,2-b]xanthen-6-one

[Synonym ]:
5,9-Dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methyl-2-buten-1-yl)-3,4-dihydro-2H,6H-pyrano[3,2-b]xanthen-6-one
5,9-dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methyl-but-2-enyl)-3,4-dihydro-2H-pyrano[3,2-b]xanthen-6-one
2H,6H-Pyrano[3,2-b]xanthen-6-one, 3,4-dihydro-5,9-dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methyl-2-buten-1-yl)-
9-hydroxycalabaxanthone
3,4-Dihydro-5,9-dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methyl-2-butenyl)-2H,6H-pyrano[3,2-b]xanthen-6-one

Biological Activity

[Description]:

3-Isomangostin, extracted from Garciniamangostana.L. shell, is a potent MutT homologue 1 (MTH1) inhibitor with an IC50 value of 52 nM. 3-isomangostin would be an attractive chemical tool for the development of anticancer agents[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[References]

[1]. Yokoyama T, et al. Discovery of a new class of MTH1 inhibitor by X-ray crystallographic screening. Eur J Med Chem. 2019 Apr 1;167:153-160.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
615.9±55.0 °C at 760 mmHg

[ Melting Point ]:
155-160ºC

[ Molecular Formula ]:
C24H26O6

[ Molecular Weight ]:
410.460

[ Flash Point ]:
212.3±25.0 °C

[ Exact Mass ]:
410.172943

[ PSA ]:
89.13000

[ LogP ]:
5.72

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.605

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream