Leteprinim Potassium Salt

Leteprinim potassium (AIT-082) is a hypoxanthine derivative neurotrophic agent. Leteprinim potassium can induce brain-derived neurotrophic factor (BDNF) mRNA production following spinal cord lesions, and nerve growth factor (NGF) mRNA production in basal forebrain. Leteprinim potassium reduces glutamate toxicity in cultured hippocampal neurons. Leteprinim potassium increases heme-oxygenase 1 and 2 mRNA levels that play role in cellular defense against reactive oxygen species. Leteprinim potassium has neuroprotective activity[1].

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

Leteprinim potassium (60 mg/kg; IP; single dosage) significantly reduced the number of apoptotic neurons in hypoxic-ischemic brain injury rat pups[1]. Animal Model: Wistar rat pups (hypoxic-ischemic brain injury induced by permanent unilateral carotid ligation)[1] Dosage: 60 mg/kg Administration: IP; single dosage Result: The number of preserved neurons was significantly high in CA1, CA3 regions of hippocampus and dentate gyrus in the left hemispheres when compared with the saline-treated group. In the right hemisphere, neuronal densities of CA1, CA2, CA3 regions of hippocampus and dentate gyrus were significantly high in neotrofin treatment group when compared with the group given saline.

[1]. Gencpınar P, et al. Effects of neotrofin on neonatal hypoxic ischemic brain injury. Neurosci Lett. 2011 Nov 14;505(2):205-10.