CCG-232601

Names

[ CAS No. ]:
1922099-21-5

[ Name ]:
CCG-232601

[Synonym ]:
3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(4-pyridinyl)benzoyl]-
N-(4-Chlorophenyl)-5,5-difluoro-1-[3-(4-pyridinyl)benzoyl]-3-piperidinecarboxamide

Biological Activity

[Description]:

CCG-232601 is a potent (IC50=0.55 uM), orally bioavailable Rho/MKL1/SRF transcriptional pathway that target transcriptional factor MRTF; inhibits the development of bleomycin-induced dermal fibrosis in mice when administered at 50mg/kg.

[References]

References 1. Hutchings KM, et al. Bioorg Med Chem Lett. 2017 Apr 15;27(8):1744-1749. View Related Products by Target Other Targets

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
683.1±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₄H₂₀ClF₂N₃O₂

[ Molecular Weight ]:
455.884

[ Flash Point ]:
366.9±31.5 °C

[ Exact Mass ]:
455.121216

[ LogP ]:
3.10

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.636

Related Compounds

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