Tenulin

Names

[ CAS No. ]:
19202-92-7

[ Name ]:
Tenulin

Biological Activity

[Description]:

Tenulin is a sesquiterpene lactone. Tenulin can be isolated from Helenium amarum[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. G W Ivie, et al. Toxicity and milk bittering properties of tenulin, the major sesquiterpene lactone constituent of Helenium amarum (bitter sneezeweed). J Agric Food Chem. 1975 Sep-Oct;23(5):845-9. J Agric Food Chem. 1975 Sep-Oct;23(5):845-9.

Chemical & Physical Properties

[ Density]:
1.263g/cm3

[ Boiling Point ]:
490.4ºC at 760mmHg

[ Molecular Formula ]:
C₁₆H₂₀O₅

[ Molecular Weight ]:
292.32700

[ Flash Point ]:
180.3ºC

[ Exact Mass ]:
292.13100

[ PSA ]:
72.83000

[ LogP ]:
1.05270

[ Vapour Pressure ]:
1.13E-11mmHg at 25°C

[ Index of Refraction ]:
1.55

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BD9640000

CHEMICAL NAME :: Ambros-2-en-12-oic acid, 6-beta,13-epoxy-8-alpha,13-dihydroxy-11-methyl-4-oxo- , gamma-lactone

CAS REGISTRY NUMBER :: 19202-92-7

LAST UPDATED :: 199012

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C17-H22-O5

MOLECULAR WEIGHT :: 306.39

WISWESSER LINE NOTATION :: T C5755 1A O DV KOV OO EUTJ C1 H1 N1Q N1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 185 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - food intake (animal) Gastrointestinal - peritonitis

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: DNA inhibition

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Ascites tumor

DOSE/DURATION :: 2143 umol/L

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 67,1235,1978