Tenulin

Names

[ CAS No. ]:
19202-92-7

[ Name ]:
Tenulin

Biological Activity

[Description]:

Tenulin is a sesquiterpene lactone. Tenulin can be isolated from Helenium amarum[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[References]

[1]. G W Ivie, et al. Toxicity and milk bittering properties of tenulin, the major sesquiterpene lactone constituent of Helenium amarum (bitter sneezeweed). J Agric Food Chem. 1975 Sep-Oct;23(5):845-9. J Agric Food Chem. 1975 Sep-Oct;23(5):845-9.  

Chemical & Physical Properties

[ Density]:
1.263g/cm3

[ Boiling Point ]:
490.4ºC at 760mmHg

[ Molecular Formula ]:
C16H20O5

[ Molecular Weight ]:
292.32700

[ Flash Point ]:
180.3ºC

[ Exact Mass ]:
292.13100

[ PSA ]:
72.83000

[ LogP ]:
1.05270

[ Vapour Pressure ]:
1.13E-11mmHg at 25°C

[ Index of Refraction ]:
1.55

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
BD9640000
CHEMICAL NAME :
Ambros-2-en-12-oic acid, 6-beta,13-epoxy-8-alpha,13-dihydroxy-11-methyl-4-oxo- , gamma-lactone
CAS REGISTRY NUMBER :
19202-92-7
LAST UPDATED :
199012
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C17-H22-O5
MOLECULAR WEIGHT :
306.39
WISWESSER LINE NOTATION :
T C5755 1A O DV KOV OO EUTJ C1 H1 N1Q N1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
185 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - food intake (animal) Gastrointestinal - peritonitis
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
1200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
DNA inhibition

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Rodent - mouse Ascites tumor
DOSE/DURATION :
2143 umol/L
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 67,1235,1978

Related Compounds

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