FCPR03

FCPR03 is a novel potent, selective PDE4 inhibitor with IC50 of 60, 31 and 47 nM for PDE4CAT (PDE4 catalytic domain), PDE4B1 and PDE4D7, respectively; displays >2,000-fold selectivity over other PDEs; effectively increases the production of cAMP, promotes CREB phosphorylation, and inhibits NF-κB activation both in vitro and in vivo; displays anti-neuroinflammation potential, promising antidepressant-like effects in vivo.

References 1. Zou ZQ, et al. J Pharmacol Exp Ther. 2017 Jul;362(1):67-77. 2. Zhou ZZ, et al. ACS Chem Neurosci. 2017 Jan 18;8(1):135-146. View Related Products by Target Phosphodiesterase (PDE)