1917347-65-9
1917347-65-9 structure
- Name: FCPR03
- Chemical Name: FCPR03
- CAS Number: 1917347-65-9
- Molecular Formula: C15H19F2NO3
- Molecular Weight: 299.318
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
- Create Date: 2020-01-11 18:53:50
- Modify Date: 2024-01-17 17:07:38
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FCPR03 is a novel potent, selective PDE4 inhibitor with IC50 of 60, 31 and 47 nM for PDE4CAT (PDE4 catalytic domain), PDE4B1 and PDE4D7, respectively; displays >2,000-fold selectivity over other PDEs; effectively increases the production of cAMP, promotes CREB phosphorylation, and inhibits NF-κB activation both in vitro and in vivo; displays anti-neuroinflammation potential, promising antidepressant-like effects in vivo.
| Name | FCPR03 |
|---|
| Description | FCPR03 is a novel potent, selective PDE4 inhibitor with IC50 of 60, 31 and 47 nM for PDE4CAT (PDE4 catalytic domain), PDE4B1 and PDE4D7, respectively; displays >2,000-fold selectivity over other PDEs; effectively increases the production of cAMP, promotes CREB phosphorylation, and inhibits NF-κB activation both in vitro and in vivo; displays anti-neuroinflammation potential, promising antidepressant-like effects in vivo. |
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| References | References 1. Zou ZQ, et al. J Pharmacol Exp Ther. 2017 Jul;362(1):67-77. 2. Zhou ZZ, et al. ACS Chem Neurosci. 2017 Jan 18;8(1):135-146. View Related Products by Target Phosphodiesterase (PDE) |
| Molecular Formula | C15H19F2NO3 |
|---|---|
| Molecular Weight | 299.318 |