Ezurpimtrostat hydrochloride

Names

[ CAS No. ]:
1914148-73-4

[ Name ]:
Ezurpimtrostat hydrochloride

Biological Activity

[Description]:

Ezurpimtrostat hydrochloride (compound 2-3) is a potent and orally active anti-fibrotic agent. Ezurpimtrostat hydrochloride reduces significantly the liver fibrosis in DEN (diethyl nitrosamine) cirrhotic rat model. Ezurpimtrostat hydrochloride can be used for the research of fibrosis, cancer, autophagy and cathepsins B (CTSB), L (CTSL) and D (CTSD) related diseases [1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

Research Areas >> Metabolic Disease

[In Vivo]

Ezurpimtrostat hydrochloride (compound 2-3) (15 mg/kg/day, PO, for 6 weeks) significantly reduces the area of liver fibrosis and the level of collagen fibers deposition (by 41.0%) in DEN cirrhotic rat model[1].

[References]

[1]. Philippe Halfon, et al. Substituted 2,4 diamino-quinoline as new medicament for fibrosis, autophagy and cathepsins b (ctsb), l (ctsl) and d (ctsd) related diseases. EP3620164A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₃₂Cl₂N₄

[ Molecular Weight ]:
459.45

Related Compounds

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