19,20-Epoxycytochalasin D

Names

[ CAS No. ]:
191349-10-7

[ Name ]:
19,20-Epoxycytochalasin D

[Synonym ]:
(1aR,2R,4S,6E,7aR,8S,10S,10aR,11S,13aR,14aS)-11-Benzyl-2,8-dihydroxy-2,4,10-trimethyl-9-methylene-3,13-dioxo-2,3,4,5,7a,8,9,10,10a,11,12,13,14,14a-tetradecahydro-1aH-oxireno[9,10]cycloundeca[1,2-d]isoindol-14-yl acetate
19,20-Epoxycytochalasin D
3H-Oxireno[9,10]cycloundec[1,2-d]isoindole-3,13(4H)-dione, 14-(acetyloxy)-1a,2,5,7a,8,9,10,10a,11,12,14,14a-dodecahydro-2,8-dihydroxy-2,4,10-trimethyl-9-methylene-11-(phenylmethyl)-, (1aR,2R,4S,6E,7aR,8S,10S,10aR,11S,13aR,14aS)-

Biological Activity

[Description]:

19,20-Epoxycytochalasin D, a cytochalasin, is a fungal metabolite from Nemania sp. 19,20-Epoxycytochalasin D shows potent in vitro antiplasmodial activity and phytotoxicity[1].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

[Target]

Microbial Metabolite

[In Vitro]

19,20-Epoxycytochalasin D shows moderate toxicity to BT-549 and LLC-PK11 cell lines, with IC50 values of 7.84 µM and 8.4 µM, respectively[1].

[References]

[1]. Mallika Kumarihamy, et al. Antiplasmodial and Cytotoxic Cytochalasins from an Endophytic Fungus, Nemania sp. UM10M, Isolated from a Diseased Torreya taxifolia Leaf. Molecules. 2019 Feb 21;24(4):777.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
735.1±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₀H₃₇NO₇

[ Molecular Weight ]:
523.617

[ Flash Point ]:
398.4±32.9 °C

[ Exact Mass ]:
523.257019

[ LogP ]:
3.45

[ Vapour Pressure ]:
0.0±2.5 mmHg at 25°C

[ Index of Refraction ]:
1.605

[ Storage condition ]:
-20°C

Related Compounds

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