1-Deoxynojirimycin

Names

[ CAS No. ]:
19130-96-2

[ Name ]:
1-Deoxynojirimycin

[Synonym ]:
(2R,3R,4R,5S)-2-Hydroxymethyl-3,4,5-trihydroxypiperidine
3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2R,3R,4R,5S)-
D-5-Amino-1,5-dideoxyglucopyranose
deoxynojirimycin
MFCD00063474
MORANOLINE
(2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-triol
Duvoglustat
(2R,3R,4R,5S)-2-(Hydroxymethyl)-3,4,5-piperidinetriol
1,5-Dideoxy-1,5-imino-D-glucitol
(+)-1-deoxynojirimycin
1-Deoxy-Nojirimycin
desoxynojirimycin
(2R,3R,4R,5S)-2-Hydroxymethyl-piperidine-3,4,5-triol
S-GI
[2R-(2a,3b,4a,5b)]-2-(Hydroxymethyl)-3,4,5-piperidinetriol
nojirimycin, deoxy-

Biological Activity

[Description]:

1-Deoxynojirimycin (DNJ, Duvoglustat) is a potent α-glucosidase inhibitor, suppresses postprandial blood glucose, thereby possibly preventing diabetes mellitus. Target: α-glucosidase1-Deoxynojirimycin is an alpha-glucosidase inhibitor, most commonly found in mulberry leaves. Although it can be obtained in small quantities by brewing an herbal tea from mulberry leaves, interest in commercial production has led to research on developing mulberry tea higher in DNJ, and on alternate routes of production, such as via Bacillusspecies.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[References]

[1]. Chaluntorn Vichasilp,et al. Development of high 1-deoxynojirimycin (DNJ) content mulberry tea and use of response surface methodology to optimize tea-making conditions for highest DNJ extraction. LWT - Food Science and Technology. Volume 45, Issue 2, Marc

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
361.1±42.0 °C at 760 mmHg

[ Melting Point ]:
195-196°C

[ Molecular Formula ]:
C₆H₁₃NO₄

[ Molecular Weight ]:
163.172

[ Flash Point ]:
197.3±18.5 °C

[ Exact Mass ]:
163.084457

[ PSA ]:
92.95000

[ LogP ]:
-2.10

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.582

[ Storage condition ]:
Desiccate at +4°C

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38:Irritating to eyes, respiratory system and skin .

[ Safety Phrases ]:
S26-S37/39-S24/25

[ WGK Germany ]:
3

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%