GGTI-2147

Names

[ CAS No. ]:
191102-87-1

[ Name ]:
GGTI-2147

[Synonym ]:
Methyl N-{4-[(1H-imidazol-5-ylmethyl)amino]-2-(1-naphthyl)benzoyl}-L-leucinate
methyl N-{4-[(1H-imidazol-4-ylmethyl)amino]-2-(naphthalen-1-yl)benzoyl}-L-leucinate
L-Leucine, N-[4-[(1H-imidazol-5-ylmethyl)amino]-2-(1-naphthalenyl)benzoyl]-, methyl ester

Biological Activity

[Description]:

GGTI-2147 is a potent GGTase I inhibitor. GGTI-2147 blocks geranyl-geranylation of Rap1A and reduces the activity of Rac1 (one of substrates for GGTI) and ameliorates the OGD/R-induced neuronal apoptosis.GGTI-2147 can be used for neurodevelopmental disorders research, such as autism, depression, and schizophrenia[1].

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS

Research Areas >> Neurological Disease

[References]

[1]. Shangfeng Gao, et al. Astrocyte GGTI-mediated Rac1 prenylation upregulates NF-κB expression and promotes neuronal apoptosis following hypoxia/ischemia. Neuropharmacology. 2016 Apr:103:44-56.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
710.6±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₈H₃₀N₄O₃

[ Molecular Weight ]:
470.563

[ Flash Point ]:
383.5±32.9 °C

[ Exact Mass ]:
470.231781

[ LogP ]:
4.23

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.640

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.