Ezetimibe phenoxy glucuronide

Names

[ CAS No. ]:
190448-57-8

[ Name ]:
Ezetimibe phenoxy glucuronide

[Synonym ]:
Ezetimibe Phenoxy Glucuronide
ezetimibe-glucuronide
EZM-G

Biological Activity

[Description]:

Ezetimibe phenoxy glucuronide is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity[1]. Ezetimibe is a potent cholesterol absorption inhibitor[2].

[Related Catalog]:

Research Areas >> Metabolic Disease

[In Vitro]

After oral administration, Ezetimibe is absorbed in the small intestine and more than 80% of Ezetimibe metabolized to Ezetimibe Glucuronide[1].

[References]

[1]. Stolk MF, et al. Severe hepatic side effects of ezetimibe. Clin Gastroenterol Hepatol. 2006 Jul;4(7):908-11.

[2]. Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532.

Chemical & Physical Properties

[ Melting Point ]:
140-150ºC

[ Molecular Formula ]:
C₃₀H₂₉F₂NO₉

[ Molecular Weight ]:
585.54900

[ Exact Mass ]:
585.18100

[ PSA ]:
156.99000

[ LogP ]:
2.51870

[ Index of Refraction ]:
1.65

Related Compounds

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