MT16-205
Names
[ CAS No. ]:
1895051-79-2
[ Name ]:
MT16-205
Biological Activity
[Description]:
MT16-205 (MT 16-205) is a potent, selective, covalent UCHL1 inhibitor with IC50 of 600 nM, no inhibition agianst UCHL3 (IC50>10 uM).MT16-205 inhibited both UCHL1 and the structurally unrelated DUB USP30 with similar potency.MT16-205 displayed cell proliferation cytotoxicity in human embryonic kidney cells (HEK293) with IC50 of 350 nM, MT16-205 effectively engaged UCHL1 in cells with IC50 of 830 nM.
[References]
1. Nattawadee Panyain, et al. RSC Med Chem. 2021 Aug 16;12(11):1935-1943.
Chemical & Physical Properties
[ Molecular Formula ]:
C17H14N4Os
[ Molecular Weight ]:
322.386