Salicortin

Names

[ Name ]:
Salicortin

[Synonym ]:
MFCD32202744

Biological Activity

[Description]:

Salicortin, a phenolic glycoside, has been isolated from many plants such as Populus and Salix species. Salicortin inhibits osteoclast differentiation and bone resorption by down-regulating JNK and NF-κB/NFATc1 signaling pathways. Salicortin has anti-amnesic, anti-adipogenic, and immune-modulatory activity[1].

[Related Catalog]:

Signaling Pathways >> MAPK/ERK Pathway >> JNK

[Target]

JNK

NF-κB

[In Vitro]

Salicortin (100 μM; 2 hours) almost completely retards the phosphorylation of IκBα[1]. Western Blot Analysis[1] Cell Line: Mouse bone marrow macrophage (BMM) Concentration: 100 μM Incubation Time: 2 hours Result: Retarded the phosphorylation of IκBα.

[References]

[1]. Nie S, et al. Salicortin inhibits osteoclast differentiation and bone resorption by down-regulating JNK and NF-κB/NFATc1 signaling pathways. Biochem Biophys Res Commun. 2016 Jan 29;470(1):61-67.

Chemical & Physical Properties

[ Melting Point ]:
141-142 °C

[ Molecular Formula ]:
C₂₀H₂₄O₁₀

[ Molecular Weight ]:
424.40

Related Compounds

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