Actinomycin X2

Names

[ Name ]:
Actinomycin X2

[Synonym ]:
5'-Deoxy(Methylthio-d3)adenosine
3h-phenoxazine,actinomycindderiv.
[A3-(4-oxo-L-proline)]-actinomycin-D
5'-S-(Methyl-d3)thioadenosine
3a-(4-oxo-l-proline)-actinomycin
5'-(Methylthio-d3)adenosine
actinomycin-V
ACTINOMYCIN X2

Biological Activity

[Description]:

Actinomycin X2 (Actinomycin V), produced by many Streptomyces sp., shows strong inhibition of MRSA with a minimum inhibitory concentration (MIC) value of 0.25 μg/mL. Actinomycin X2 can be used for cancer and bacterial infection[1].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Zhiyu Chen, et al. Anti-MRSA Activity of Actinomycin X 2 and Collismycin A Produced by Streptomyces globisporusWA5-2-37 From the Intestinal Tract of American Cockroach ( Periplaneta americana). Front Microbiol. 2020 Apr 7;11:555.

Chemical & Physical Properties

[ Density]:
1.44g/cm3

[ Boiling Point ]:
1411.4ºC at 760mmHg

[ Molecular Formula ]:
C₆₂H₈₄N₁₂O₁₇

[ Molecular Weight ]:
1269.40000

[ Flash Point ]:
807.4ºC

[ Exact Mass ]:
1268.61000

[ PSA ]:
377.05000

[ LogP ]:
1.55260

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.661

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AU2010000

CHEMICAL NAME :: Actinomycin X2

CAS REGISTRY NUMBER :: 18865-48-0

LAST UPDATED :: 199706

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C62-H84-N12-O17

MOLECULAR WEIGHT :: 1269.58

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 38,1625,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 38KLAC "Structure-Activity Relationship among the Semisynthetic Antibiotics," Perlman, D., ed., New York, Academic Press, 1977 Volume(issue)/page/year: -,427,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 4(2),48,1980

Safety Information

[ Hazard Codes ]:
T+: Very toxic;

[ Risk Phrases ]:
26/27/28-63

[ Safety Phrases ]:
22-36/37/39-45

[ RIDADR ]:
UN 2811 6.1/PG 2