dBET57

Names

[ Name ]:
dBET57

Biological Activity

[Description]:

dBET57 is a potent and selective heterobifunctional degrader of BRD4 based on the PROTAC technology, with a DC50/5h of 500 nM for BRD4BD1, and is inactive on BRD4BD2[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC

Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain

[Target]

DC50/5h: 500 nM (BRD4BD1)[1]

[References]

[1]. Nowak RP, et al. Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat Chem Biol. 2018 Jul;14(7):706-714.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₄H₃₁ClN₈O₅S

[ Molecular Weight ]:
699.18

Related Compounds

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