Pellitorine

Names

[ Name ]:
Pellitorine

[Synonym ]:
methyl trans
(2E,4E)-N-Isobutyl-2,4-decadienamide
trans-2,4-hexadienoate
(2E,4E)-N-Isobutyldeca-2,4-dienamide
pellitorine
METHYL T2 T4 HEXADIENOATE
E,E-N-Isobutyl-2,4-decadienamide
2,4-Decadienamide, N-(2-methylpropyl)-, (2E,4E)-
Pellitorin
Methyl trans,trans-sorbate
(2E,4E)-N-(2-methylpropyl)deca-2,4-dienamide
SORBIC ACID METHYL ESTER

Biological Activity

[Description]:

Pellitorine is a compound isolated from the roots of Piper nigrum. Pellitorine shows strong cytotoxic activities against HL60 and MCT-7 cell lines. Pellitorine has the potential for the research of cancer diseases[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Ee GC, et al. Pellitorine, a potential anti-cancer lead compound against HL6 and MCT-7 cell lines and microbial transformation of piperine from Piper Nigrum. Molecules. 2010;15(4):2398-2404.

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
368.7±15.0 °C at 760 mmHg

[ Melting Point ]:
88-89ºC

[ Molecular Formula ]:
C₁₄H₂₅NO

[ Molecular Weight ]:
223.354

[ Flash Point ]:
224.6±5.3 °C

[ Exact Mass ]:
223.193619

[ PSA ]:
29.10000

[ LogP ]:
3.92

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.470

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HD3510500

CHEMICAL NAME :: 2,4-Decadienamide, N-isobutyl-, (E,E)-

CAS REGISTRY NUMBER :: 18836-52-7

BEILSTEIN REFERENCE NO. :: 1725967

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C14-H25-N-O

MOLECULAR WEIGHT :: 223.40

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 700 mg/kg

SEX/DURATION :: female 1-7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

REFERENCE :: IJSIDW Indian Journal of Pharmaceutical Sciences. (Kalina, Santa Cruz (East), Bombay 400 029, India) V.40(2)- 1978- Volume(issue)/page/year: 40,113,1978

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2924199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%