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GSK-3β inhibitor 1

Names

[ CAS No. ]:
187325-53-7

[ Name ]:
GSK-3β inhibitor 1

Biological Activity

[Description]:

GSK-3β inhibitor 1 (compound 3a) is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy, with an IC50 of 4.9 nM[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> GSK-3
Research Areas >> Metabolic Disease
Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3

[Target]

GSK-3β:4.9 nM (IC50)


[References]

[1]. Lozinskaya NA, et al. Synthesis and biological evaluation of 3-substituted 2-oxindole derivatives as new glycogen synthase kinase 3β inhibitors. Bioorg Med Chem. 2019 May 1;27(9):1804-1817.

Chemical & Physical Properties

[ Molecular Formula ]:
C14H10N2O

[ Molecular Weight ]:
222.24

[ Storage condition ]:
-20°C

Related Compounds