DC661

Names

[ Name ]:
DC661

Biological Activity

[Description]:

DC661 is a potent palmitoyl-protein thioesterase 1 (PPT1) inhibitor, inhibits autophagy, and acts as an anti-lysosomal agent. Anti-cancer activity[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Autophagy >> Autophagy

[Target]

PPT1, autophagy[1]

[In Vitro]

DC661 (0.1 and 10 µM) accumulates autophagic vesicles in melanoma cells[1].

[References]

[1]. Rebecca VW, et al. PPT1 Promotes Tumor Growth and Is the Molecular Target of Chloroquine Derivatives in Cancer. ancer Discov. 2019 Feb;9(2):220-229.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₁H₃₉Cl₂N₅

[ Molecular Weight ]:
552.58

[ Storage condition ]:
2-8℃

Related Compounds

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