1872387-43-3

1872387-43-3 structure

Name: DC661
Chemical Name: DC661
CAS Number: 1872387-43-3
Molecular Formula: C₃₁H₃₉Cl₂N₅
Molecular Weight: 552.58
Catalog: Signaling Pathways Autophagy Autophagy
Create Date: 2019-03-30 16:18:34
Modify Date: 2025-08-25 16:56:48
DC661 is a potent palmitoyl-protein thioesterase 1 (PPT1) inhibitor, inhibits autophagy, and acts as an anti-lysosomal agent. Anti-cancer activity[1].

Name	DC661

Description	DC661 is a potent palmitoyl-protein thioesterase 1 (PPT1) inhibitor, inhibits autophagy, and acts as an anti-lysosomal agent. Anti-cancer activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy
Target	PPT1, autophagy[1]
In Vitro	DC661 (0.1 and 10 µM) accumulates autophagic vesicles in melanoma cells[1].
References	[1]. Rebecca VW, et al. PPT1 Promotes Tumor Growth and Is the Molecular Target of Chloroquine Derivatives in Cancer. ancer Discov. 2019 Feb;9(2):220-229.