L-Cysteine methyl ester hydrochloride

Names

[ Name ]:
L-Cysteine methyl ester hydrochloride

[Synonym ]:
Actiol
H-Cys-OMe·HCl
Mecystein HCl
cysteine methyl ester hydrochloride
methyl L-cysteinate hydrochloride
Acdrile
MFCD00038985
Methyl L-cysteinate hydrochloride (1:1)
EINECS 242-435-0
L-Cysteine, methyl ester, hydrochloride (1:1)
hydrochloride*H-Cys-OMe
Methyl cysteine HCl
H-Cys-OMe.HCl
L-Cysteine Methyl Ester Hydrochloride
L-Cysteinemethylesterhydrochloride

Biological Activity

[Description]:

Mecysteine hydrochloride is an antitussive, and an expectorant agent, used to relieve breathing difficulties caused by mucus.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
197.2ºC at 760 mmHg

[ Melting Point ]:
142 °C (dec.)(lit.)

[ Molecular Formula ]:
C₄H₁₀ClNO₂S

[ Molecular Weight ]:
171.646

[ Flash Point ]:
73.1ºC

[ Exact Mass ]:
171.012070

[ PSA ]:
91.12000

[ LogP ]:
0.91880

[ Vapour Pressure ]:
0.384mmHg at 25°C

[ Index of Refraction ]:
-2.5 ° (C=20, MeOH)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HA2460000

CHEMICAL NAME :: Cysteine, methyl ester, hydrochloride, L-

CAS REGISTRY NUMBER :: 18598-63-5

LAST UPDATED :: 199210

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C4-H9-N-O2-S.Cl-H

MOLECULAR WEIGHT :: 171.66

WISWESSER LINE NOTATION :: SH1YZVO1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 24,2331,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1340 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,829,1982 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 60 gm/kg/30D-C

TOXIC EFFECTS :: Liver - other changes Kidney, Ureter, Bladder - other changes Blood - normocytic anemia

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 14,1407,1980

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
HA2460000

[ HS Code ]:
2930909090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

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Chem. Pharm. Bull. 63(3) , 187-94, (2015)

Two new steroidal glycosides (1 and 2), together with 15 known compounds (3-17) were isolated from the fibrous roots of Ophiopogon japonicus, and three new steroidal glycosides (18-20), together with ...

Triterpene glycosides and other polar constituents of shea (Vitellaria paradoxa) kernels and their bioactivities.

Phytochemistry 108 , 157-70, (2014)

The MeOH extract of defatted shea (Vitellaria paradoxa; Sapotaceae) kernels was investigated for its constituents, and fifteen oleanane-type triterpene acids and glycosides, two steroid glucosides, tw...

The role of hydrogen bonding in the selectivity of L-cysteine methyl ester (CYSM) and L-cysteine ethyl ester (CYSE) for chloride ion.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 61(5) , 845-54, (2005)

The interaction of cysteamine (CY), L-cysteine methyl ester (CYSM), and L-cysteine ethyl ester (CYSE) with nitrate, sulfate, perchlorate, dihydrogen phosphate, and chloride ions was investigated using...