IPN60090

Names

[ Name ]:
IPN60090

Biological Activity

[Description]:

IPN-60090 is an orally bioavailable and selective inhibitor of GLS1 (the kidney-type glutaminase), an important enzyme for metabolic energy production. IPN-60090 can be used in the research of GLS1-mediated diseases[1][2].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

Research Areas >> Neurological Disease

[Target]

GLS1[1]

[In Vitro]

IPN-60090 (Example 1) has an IC50 against GLS1 and an EC50 against A549 cell proliferation of <100 nM[2].

[References]

[1]. Maria Emilia Di Francesco, et al. Gls1 inhibitors for treating disease. WO2016004404A2.

[2]. Philip Jones, et al. Salt forms and polymorphs of (r)-1-(4-(6-(2-(4-(3,3-difluorocyclobutoxy)-6-methylpyridin-2-yl)acetamido) pyridazin-3-yl)-2-fluorobutyl)-n-methyl-1h-1,2,3-triazole-4-carboxamide. US20170174661A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₂₇F₃N₈O₃

[ Molecular Weight ]:
532.52

Related Compounds

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