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TAS4464 hydrochloride

Names

[ CAS No. ]:
1848959-11-4

[ Name ]:
TAS4464 hydrochloride

[Synonym ]:
MFCD32067968

Biological Activity

[Description]:

TAS4464 (hydrochloride) is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE), with an IC50 of 0.955 nM[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> NEDD8-activating Enzyme

[Target]

IC50：0.955 nM (NAE)[1]


[References]

[1]. Yoshimura C, et al. TAS4464, a highly potent and selective inhibitor of NEDD8 activating enzyme, suppresses neddylation and shows antitumor activity in diverse cancer models. Mol Cancer Ther. 2019 May 15.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H24ClFN6O6S

[ Molecular Weight ]:
542.97

Related Compounds