chlornitrofen
Names
[ CAS No. ]:
1836-77-7
[ Name ]:
chlornitrofen
[Synonym ]:
p-nitrophenyl 2,4,6-trichlorophenyl ether
2,4,6-trichloro-4'-nitro-diphenylether
1,3,5-Trichloro-2-(4-nitrophenoxy)benzene 4-Nitrophenyl 2,4,6-trichlorophenyl ether
MC 338
1,3,5-trichloro-2-(4-nitrophenoxy)benzene
4-nitrophenyl 2,4,6-trichlorophenyl ether
4-nitrophenyl-2,4,6-trichlorophenyl ether
EINECS 217-407-6
Chlornitrofen
CNP 1032
2,4,6-Trichlorophenyl 4-nitrophenyl ether
Chemical & Physical Properties
[ Density]:
1.533 g/cm3
[ Boiling Point ]:
370.4ºC at 760 mmHg
[ Melting Point ]:
105-106°
[ Molecular Formula ]:
C12H6Cl3NO3
[ Molecular Weight ]:
318.54000
[ Flash Point ]:
177.8ºC
[ Exact Mass ]:
316.94100
[ PSA ]:
55.05000
[ LogP ]:
5.87050
[ Index of Refraction ]:
1.731
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KO2700000
- CHEMICAL NAME :
- Ether, p-nitrophenyl 2,4,6-trichlorophenyl
- CAS REGISTRY NUMBER :
- 1836-77-7
- BEILSTEIN REFERENCE NO. :
- 1890443
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C12-H6-Cl3-N-O3
- MOLECULAR WEIGHT :
- 318.54
- WISWESSER LINE NOTATION :
- WNR DOR BG DG FG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >520 mg/m3/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - domestic
- DOSE/DURATION :
- 2680 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 10 gm/kg
- SEX/DURATION :
- female 6-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
MUTATION DATA
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 100 ug/plate
- REFERENCE :
- CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 44,133,1983
Safety Information
[ Symbol ]:
GHS09
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H410
[ Precautionary Statements ]:
P273-P501
[ Hazard Codes ]:
Xi: Irritant;F: Flammable;
[ Risk Phrases ]:
50/53
[ Safety Phrases ]:
60-61
[ RIDADR ]:
UN 3077 9 / PGIII
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Mutat. Res. 346(1) , 57-60, (1995)
Three kinds of diphenyl ether herbicides, 4-nitrophenyl 2,4,6-trichlorophenyl ether (CNP, chlornitrofen), 2,4-dichlorophenyl 3-methoxy-4-nitrophenyl ether (chlomethoxynil) and 2,4-dichlorophenyl 3-met...
Cytotoxic and porphyrinogenic effects of diphenyl ethers in cultured rat hepatocytes: chlornitrofen (CNP), CNP-amino, chlomethoxyfen and bifenox.Food Chem. Toxicol. 37(1) , 69-74, (1999)
We studied the cytotoxic and porphyrinogenic effects of four diphenyl ethers (DPEs), chlornitrofen (CNP), CNP-amino, chlomethoxyfen and bifenox, in rat hepatocytes cultured on Matrigel. Cytotoxicity w...
Fate and behavior of herbicides, butachlor, CNP, chlomethoxynil, and simetryne in river water, shellfish, and sediments of the Ishikari River.Bull. Environ. Contam. Toxicol. 39(4) , 555-62, (1987)