4-(5-HYDROXYMETHYLIMIDAZOL-1-YLMETHYL)BENZONITRILE

Names

[ Name ]:
4-(5-HYDROXYMETHYLIMIDAZOL-1-YLMETHYL)BENZONITRILE

Biological Activity

[Description]:

CYP19A1/CYP11B2-IN-1 (Compound X21) is a potent and selective aromatase and aldosterone synthase dual inhibitor with IC50s of 2.3 nM and 29 nM for aromatase (CYP19A1) and aldosterone synthase (CYP11B2), respectively. CYP19A1/CYP11B2-IN-1 has excellent antiproliferative and pro-apoptotic activity against the cancer cell. CYP19A1/CYP11B2-IN-1 can be used for research of breast cancer[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450

[References]

[1]. Tinivella A, et al. Discovery of a Potent Dual Inhibitor of Aromatase and Aldosterone Synthase. ACS Pharmacology & Translational Science. 2023 Nov 23.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₂H₁₁N₃O

[ Molecular Weight ]:
213.23500

[ Exact Mass ]:
213.09000

[ PSA ]:
61.84000

[ LogP ]:
1.29538

Synthetic Route

Click to get detail synthetic route

Related Compounds

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