L778123 dihydrochloride

Names

[ Name ]:
L778123 dihydrochloride

Biological Activity

[Description]:

L-778123 is an inhibitor of FPTase and GGPTase-I, which was developed in part because it can completely inhibit Ki-Ras prenylation. The combination of L-778,123 and radiotherapy at dose level 1 showed acceptable toxicity in patients with locally advanced pancreatic cancer. Radiosensitization of a patient-derived pancreatic cancer cell line was observed.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₂Cl₃N₅O

[ Molecular Weight ]:
478.802

Related Compounds

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