CPPG

Names

[ Name ]:
CPPG

[Synonym ]:
CPPG
Water,sterile filtered

Biological Activity

[Description]:

CPPG ((RS)-CPPG) is a potent group II/III mGlu receptor antagonist. CPPG exhibits some selectivity (approximately 20 fold) for group III (IC50=2.2 nM) over group II (IC50=46.2 nM) mGlu receptors in the rat cerebral cortex. CPPG has weak effects at group I mGlu receptors[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR

Research Areas >> Neurological Disease

[In Vitro]

CPPG ((RS)-CPPG) potently reversed both L-AP4 (IC50=2.2 nM)- and L-CCG-I (IC50=46.2 nM) -mediated inhibition of forskolin-stimulated cyclic AMP accumulation in adult rat cortical slices. CPPG is a potent antagonist against group II/III mGlu receptors in the adult rat cortex and shows moderate selectivity for group III mGlu receptors. Conversely, CPPG has weak effects at group I mGlu receptors in both the neonatal rat cortex and cultured cerebellar granule cells[1].

[References]

[1]. Toms NJ, et al. The effects of (RS)-alpha-cyclopropyl-4-phosphonophenylglycine ((RS)-CPPG), a potent and selective metabotropic glutamate receptor antagonist. Br J Pharmacol. 1996 Nov;119(5):851-4.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁H₁₄NO₅P

[ Molecular Weight ]:
271.20600

[ Exact Mass ]:
271.06100

[ PSA ]:
130.66000

[ LogP ]:
0.83850

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ RIDADR ]:
NONH for all modes of transport

Articles

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Invest. Ophthalmol. Vis. Sci. 55(7) , 4063-72, (2014)

Juvenile-onset autosomal dominant Stargardt-like macular dystrophy (STGD3) is caused by mutations in ELOVL4 (elongation of very long fatty acids-4), an elongase necessary for the biosynthesis of very ...

Neuroprotective potential of the group III mGlu receptor agonist ACPT-I in animal models of ischemic stroke: In vitro and in vivo studies.

Neuropharmacology 102 , 276-94, (2016)

In the present study, we investigated the effect of ACPT-I [(1S, 3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid], a blood-brain-barrier permeable agonist of group III mGlu receptor, against oxyge...

Distinct effects of mGlu4 receptor positive allosteric modulators at corticostriatal vs. striatopallidal synapses may differentially contribute to their antiparkinsonian action.

Neuropharmacology 85 , 166-77, (2014)

Metabotropic glutamate 4 (mGlu4) receptor is a promising target for the treatment of motor deficits in Parkinson's disease (PD). This is due in part to its localization at key basal ganglia (BG) synap...

Related Compounds

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