(R)-MLT-985

Names

[ Name ]:
(R)-MLT-985

Biological Activity

[Description]:

(R)-MLT-985 (compound 11) is a potent MALT1 protease inhibitor with an IC50 of 3 nM. (R)-MLT-985 has an IC50 of 20 nM for MALT1-dependent IL-2 production in Jurkat cells. (R)-MLT-985 suppresses growth and aberrant CARD11/BCL10/MALT1 complex signaling in ABC-DLBCL cells[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> NF-κB >> MALT1

[References]

[1]. Jean Quancard, et al. Optimization of the In Vivo Potency of Pyrazolopyrimidine MALT1 Protease Inhibitors by Reducing Metabolism and Increasing Potency in Whole Blood. J Med Chem. 2020 Dec 10;63(23):14594-14608.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₅Cl₂N₉O₂

[ Molecular Weight ]:
448.27

Related Compounds

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