JJH260

Names

[ Name ]:
JJH260

[Synonym ]:
Imidazo[1,5-a]pyrazine-1,3(2H,5H)-dione, 2-[[[4-[2-(4-chlorophenyl)ethyl]-1-piperidinyl]carbonyl]oxy]-7-[4-(dimethylamino)benzoyl]tetrahydro-
2-[({4-[2-(4-Chlorophenyl)ethyl]-1-piperidinyl}carbonyl)oxy]-7-[4-(dimethylamino)benzoyl]tetrahydroimidazo[1,5-a]pyrazine-1,3(2H,5H)-dione
JJH260

Biological Activity

[Description]:

JJH260 is AIG1inhibitor, and inhibit the fluorophosphonate reactivity and fatty acid esters of hydroxy fatty acid (FAHFA) hydrolysis activity of AIG1in HEK293T cells, with IC50 values of 0.50 μM and 0.57 μM, respectively[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> MAGL

Research Areas >> Metabolic Disease

Signaling Pathways >> Others >> Androgen Receptor

[Target]

0.50 μM (AIG1) and 0.57 μM (FAHFA) in HEK293T cells [1]

[References]

[1]. William H Parsons, et al. AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs. Nat Chem Biol. 2016 May;12(5):367-372.

[2]. Xinkang Wang, et al. Antithrombotic Effects of the Novel Small-Molecule Factor XIa Inhibitor Milvexian in a Rabbit Arteriovenous Shunt Model of Venous Thrombosis. TH Open. 2023 Apr; 7(2): e97–e104.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
703.9±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₉H₃₄ClN₅O₅

[ Molecular Weight ]:
568.06

[ Flash Point ]:
379.5±35.7 °C

[ Exact Mass ]:
567.224854

[ LogP ]:
2.99

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.662