Monomethyl auristatin E intermediate-5

Names

[ CAS No. ]:
1822810-13-8

[ Name ]:
Monomethyl auristatin E intermediate-5

Biological Activity

[Description]:

Monomethyl auristatin E intermediate-5 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[References]

[1]. Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87.  

Chemical & Physical Properties

[ Density]:
1.100±0.06 g/cm3(Predicted)

[ Boiling Point ]:
464.4±35.0 °C(Predicted)

[ Molecular Formula ]:
C19H27NO5

[ Molecular Weight ]:
349.42

Related Compounds

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