SMO-IN-2

Names

[ Name ]:
SMO-IN-2

Biological Activity

[Description]:

SMO-IN-2 (compound 1) is a potent smoothened (SMO) inhibitor with an IC50 value of 123.4 nM for hedgehog (Hh) signaling pathway. SMO-IN-2 has antiproliferative activity against human medulloblastoma cell line Daoy. Anticancer activity[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> Smo

Research Areas >> Cancer

Signaling Pathways >> Stem Cell/Wnt >> Hedgehog

[Target]

IC50: 123.4 nM (Hh)[1]

[In Vitro]

SMO-IN-2 (compound 1) has antiproliferative activity against human medulloblastoma cell line Daoy with an IC50 of 0.51 μM[1].

[References]

[1]. Ji D, et al. Design, synthesis and biological evaluation of anthranilamide derivatives as potent SMO inhibitors. Bioorg Med Chem. 2020 Mar 15;28(6):115354.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₂₅F₄N₅O₂

[ Molecular Weight ]:
503.49

Related Compounds

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