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BMS-195614

Names

[ CAS No. ]:
182135-66-6

[ Name ]:
BMS-195614

[Synonym ]:
BMS 614
BMS614
BMS 195614
BMS-614
4-[[[5,6-Dhydro-5,5-dimethyl-8-(3-quinolinyl)-2-naphthalenyl]carbonyl]amino]-benzoic acid
MFCD00952209
BMS195614
BMS-195614
4-({[5,5-Dimethyl-8-(3-quinolinyl)-5,6-dihydro-2-naphthalenyl]carbonyl}amino)benzoic acid
4-[5,6-Dihydro-5,5-dimethyl-8-(quinolin-3-yl)naphthalen-2-carboxamido] benzoic acid
Benzoic acid, 4-[[[5,6-dihydro-5,5-dimethyl-8-(3-quinolinyl)-2-naphthalenyl]carbonyl]amino]-

Biological Activity

[Description]:

BMS-195614 (BMS 614) is a neutral RARα-selective antagonist with a Ki of 2.5 nM[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> RAR/RXR

[References]

[1]. Géhin M, et al. Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists. Chem Biol. 1999;6(8):519-529.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
607.3±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C29H24N2O3

[ Molecular Weight ]:
448.51

[ Flash Point ]:
321.1±31.5 °C

[ Exact Mass ]:
448.178680

[ LogP ]:
7.05

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.693

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds